HCID 67361944, 화합물 → HCID 59152645, 화합물

HRID 1804769노트

반응식

HRID 1804769 반응식
Cl.[CH3:2][C@@H:3]1[C@@H:8]([OH:9])[CH2:7][CH2:6][N:5]([CH2:10][CH2:11][C:12]23[CH2:19][CH2:18][CH:15]([CH2:16][CH2:17]2)[NH:14][O:13]3)[CH2:4]1>CO.[Pd]>[NH2:14][CH:15]1[CH2:16][CH2:17][C:12]([CH2:11][CH2:10][N:5]2[CH2:6][CH2:7][C@H:8]([OH:9])[C@@H:3]([CH3:2])[CH2:4]2)([OH:13])[CH2:19][CH2:18]1

참가 물질

4

반응물 1

HCID 67361944HCID 67361944, 화합물

생성물 1

HCID 59152645HCID 59152645, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매2회

실험 절차

10% Pd—C (240 mg) is placed into a round-bottom flask under an argon atmosphere and covered with methanol. A solution of (3S,4S)-3-Methyl-1-[2-(2-oxa-3-aza-bicyclo[2.2.2]oct-1-yl)-ethyl]-piperidin-4-ol (13) (584 mg, 2.3 mmol) in 20 ml of methanol is added and the mixture is hydrogenated for 2 h at room temperature. Then the mixture is filtrated over celite and evaporated under reduced pressure. The product was used in the next step without further purification.

후처리

  1. filtrationThen the mixture is filtrated over celite
  2. customevaporated under reduced pressure
  3. customThe product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-a4009fd2c65949e9b785aee14017b0ef
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354431B2

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