3-Methoxyphenethyl alcohol → 4-[2-(3-methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid

반응식

[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH:9]=[C:10]([C:16]([OH:18])=[O:17])[NH:11]3)[CH2:4][CH2:3][CH2:2]1.[CH3:19][O:20][C:21]1[CH:22]=C(CCO)C=C[CH:26]=1.C(OC(C1NC2C(C=1)=C(O)C=CC=2)=O)C>>[CH3:19][O:20][C:21]1[CH:26]=[C:4]([CH2:1][CH2:5][O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH:9]=[C:10]([C:16]([OH:18])=[O:17])[NH:11]3)[CH:3]=[CH:2][CH:22]=1

참가 물질

반응물 3

HCID 787243-Methoxyphenethyl alcohol

HCID 13274763Ethyl 4-hydroxy-1H-indole-2-carboxylate

HCID 591526824-Cyclobutylmethoxy-1H-indole-2-carboxylic acid

생성물 1

HCID 591526784-[2-(3-methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid

실험 절차

4-[2-(3-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid (16k) is synthesized analogous to 16a from 2-(3-methoxy-phenyl)-ethanol and 4-hydroxy-1H-indole-2-carboxylic acid ethyl ester.

출처 및 근거

ORD 기록: ord-76ae347a0366439b94c1593a9257e4a9
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08354431B2

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