Isopropanol → 2-Isopropoxypyrimidine
반응식
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(NC(C)C)(C)C.[CH:15]([OH:18])([CH3:17])[CH3:16]>>[CH:15]([O:18][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1)([CH3:17])[CH3:16]참가 물질
4
반응 조건
- 온도
- 130 °C
실험 절차
A 2-chloropyrimidine was dissolved in isopropyl alcohol to which was added diisopropylamine. The reaction was heated in a sealed tube for ten days at 130° C. The cooled reaction mixture was concentrated, and the product purified via silica gel column chromatography to yield the 2-isopropoxypyrimidine.
후처리
- customThe cooled reaction mixture
- concentrationwas concentrated
- customthe product purified via silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-5eeae7a57a0340a0ac9a97edec8fd5c5
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741328B2
반응 노트
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