HCID 59152645, 화합물 → 4-[2-(2-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804814노트

반응식

HRID 1804814 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][O:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:13]=1[CH:14]=[C:15]([C:21]([OH:23])=O)[NH:16]2.[NH2:24][CH:25]1[CH2:30][CH2:29][C:28]([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][C@H:37]([OH:40])[C@@H:36]([CH3:41])[CH2:35]2)([OH:31])[CH2:27][CH2:26]1>>[OH:31][C:28]1([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][C@H:37]([OH:40])[C@@H:36]([CH3:41])[CH2:35]2)[CH2:29][CH2:30][CH:25]([NH:24][C:21]([C:15]2[NH:16][C:17]3[C:13]([CH:14]=2)=[C:12]([O:11][CH2:10][CH2:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:26][CH2:27]1

참가 물질

3

반응물 2

HCID 59152645HCID 59152645, 화합물HCID 591526474-[2-(2-methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid

생성물 1

HCID 250051624-[2-(2-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

실험 절차

This compound is synthesized analogously to example 1 from 4-[2-(2-methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid 16j and amine 14.

출처 및 근거

ORD 기록
ord-2466a5ad6ad54507bcaf5f09a2c06870
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354431B2

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