Acetyl chloride → 1-(6-amino-1H-indol-1-yl)ethanone

HRID 1804895

반응식

HRID 1804895 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-])=O.[C:13](Cl)(=[O:15])[CH3:14]>CC#N>[NH2:1][C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][N:10]2[C:13](=[O:15])[CH3:14])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 785026-Nitro-1H-indole

생성물 1

HCID 222777891-(6-amino-1H-indol-1-yl)ethanone

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1-(6-Amino-indol-1-yl)-ethanone (B-3) was synthesized following the general scheme above starting from 6-nitroindole and acetyl chloride. Overall yield (˜40%). HPLC ret. time 0.54 min, 10-99% CH3CN, 5 min run; ESI-MS 175.1 m/z (MH+).

후처리

  1. customOverall yield (˜40%)

출처 및 근거

ORD 기록
ord-140e2e1de8bc49a4994d7f00c4f7a454
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354427B2

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