5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid → 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl]-1,3-diaza-spiro[4.4]non-1-en-4-one

참여 물질

역할	이름	HCID	투입량
반응물	5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid	HCID 1519421	—
반응물	1-Aminocyclopentane-1-carboxamide hydrochloride	HCID 54593188	—
생성물	2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl]-1,3-diaza-spiro[4.4]non-1-en-4-one	HCID 46198882	—

반응 단계

Compound 25 was synthesized from 4a (251 mg, 0.66 mmol) and 5j (140 mg, 0.98 mmol) as a white solid (140 mg, 45%) in a manner similar to that described in Example 53. 1H NMR (400 MHz, CDCl3) δ 7.40 (d, 1H), 7.32˜7.26 (m, 3H), 7.12 (s, 1H), 7.02 (d, 2H), 2.49 (m, 2H), 2.36 (s, 3H), 2.17 (m, 2H), 1.86 (m, 4H); ESMS m/z: 473.1 (M+1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08354442B2
출처 데이터셋	uspto-grants-2013_01
ORD ID	ord-02cc754c69104117a92e1091c8875902
출처 메모	uspto-grants-2013_01