Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1805249생성일: 2026년 10월 26일
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate → Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate
https://huagongshe.com/reaction/1805249
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate | HCID 3696469 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate | HCID 22831728 | — |
반응 단계
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (1128 mg) was dissolved in MeOH (23 ml) before addition of sodium methoxide (380 mg), the reaction mixture was stirred for 2 hours in a sealed tube at 110° C. The solvent was evaporated, the product dissolved in ethyl acetate and washed with water, the organics were dried over Na2SO4, and concentrated in vacuo to afford title compound as a colourless oil. MS (ISP) 237.0 ([M+H]+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08354441B2 |
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| 출처 데이터셋 | uspto-grants-2013_01 |
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| ORD ID | ord-b44112ae04204f93bc669ab934edfad4 |
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| 출처 메모 | uspto-grants-2013_01 |
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