Acetone → 5-Fluoro-3-isopropylidene-1,3-dihydro-indol-2-one
반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH3:12][C:13]([CH3:15])=O.N1CCCCC1>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[C:13]([CH3:15])[CH3:12]참가 물질
5
실험 절차
A mixture of 5-fluoro-1,3-dihydro-indol-2-one (2.84 g, 20 mmol), acetone (2.2 mL, 30 mmol) and piperidine (0.8 mL, 8 mmol) in methanol (100 mL) was heated to reflux for 16 hours. Then the reaction mixture was allowed to cool to room temperature. The solid was collected by filtration, washed with methanol (20 mL) and dried in vacuo to afford 5-fluoro-3-isopropylidene-1,3-dihydro-indol-2-one (2.6 g, 68%) as powder.
후처리
- temperaturewas heated
- temperatureto reflux for 16 hours
- filtrationThe solid was collected by filtration
- washwashed with methanol (20 mL)
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-812991ae89c84fd390eb3e99cbf27e4b
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08354443B2
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