Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 4-Methyl-sulfonylpyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Hydrogen Peroxide | HCID 784 | — |
| 반응물 | 4-(Methylthio)pyridine | HCID 140938 | — |
| 반응물 | 4-Methanesulfonylpyridine | HCID 292487 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 촉매 | Sodium tungstate | HCID 26052 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Methyl-sulfonylpyridine | HCID 86598630 | — |
반응 단계
4-Methylsulfonylpyridine may be prepared by carrying out the procedure as described in Example 20, starting with 14 g of sodium tungstate, 4 cm3 of water, 0.05 cm3 of 100% acetic acid, 3.3 g of 4-methylsulfanyl-pyridine, 6.5 cm3 of 30% hydrogen peroxide and then 0.25 cm3 of 32% aqueous ammonia and 1 cm3 of 37.5% aqueous solution of sodium hydrogen sulfite. The crude oil obtained is crystallized with 10 cm3 of diisopropyl ether, the crystals are filtered, drained and dried under reduced pressure (2.7 kPa). 2.6 g of 4-methyl-sulfonylpyridine are obtained in the form of white crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741316B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0849b5bd46324f2ca8a266329f580a42 |
| 출처 메모 | uspto-grants-2010_06 |