Potassium Carbonate → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-formyl-3-furanyl)-1H-indole-7-carboxamide

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Bromo-2-furaldehyde	HCID 2757010	—
반응물	3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamide	HCID 59828929	—
촉매	HCID 178418397	HCID 178418397	—
용매	Water	HCID 962	—
용매	1,4-Dioxane	HCID 31275	—
생성물	3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-formyl-3-furanyl)-1H-indole-7-carboxamide	HCID 86631030	122.8%

반응 조건

온도	150 °C

반응 단계

To a solution of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamide (50 mg, 0.11 mmol) in dioxane (3.0 mL) and H2O (1.0 mL) was added 4-bromo-2-furancarbaldehyde (58 mg, 0.33 mmol), potassium carbonate (89.8 mg, 0.66 mmol), and tetrakis(triphenylphosphine)palladium(0) (14 mg, 0.012 mmol). The reaction was heated in the microwave for 20 min at 150° C. to give 58 mg of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-formyl-3-furanyl)-1H-indole-7-carboxamide.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08354406B2
출처 데이터셋	uspto-grants-2013_01
ORD ID	ord-4afe6abac1324ceda0cf0b9277966a6b
출처 메모	uspto-grants-2013_01