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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1806493생성일: 2026년 10월 26일

Prolinol, (R)- → 5-(5-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide

https://huagongshe.com/reaction/1806493

반응식

참여 물질

역할이름HCID투입량
반응물Prolinol, (R)-HCID 2724541—
반응물5-(5-{[(2R)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamideHCID 57732666—
생성물5-(5-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamideHCID 5773262253.1%

반응 단계

The title compound was prepared according to the general procedure of 5-(5-{[(2R)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide, substituting (3S)-3-pyrrolidinol (90.13 mg, 1.20 mmol) for (2R)-2-pyrrolidinylmethanol to afford 12.8 mg of the title compound (53.1%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08354406B2
출처 데이터셋uspto-grants-2013_01
ORD IDord-e973d96bdbf54f7083e03a39162ae245
출처 메모uspto-grants-2013_01