Dichloromethane → (2R,3S,4R,5S)-5-tert-Butyl-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-phenyl)-4-cyano-pyrrolidine-2-carboxylic acid tert-butyl ester

반응식

[C:1]([O:5][C:6](=[O:14])[CH2:7]/[N:8]=[CH:9]/[C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:4])([CH3:3])[CH3:2].[Cl:15][C:16]1[C:17]([F:33])=[C:18](/[CH:22]=[C:23](/[C:26]2[CH:31]=[CH:30]C(Cl)=[CH:28][CH:27]=2)\[C:24]#[N:25])[CH:19]=[CH:20][CH:21]=1.C(N(CC)CC)C.Cl[CH2:42][Cl:43]>>[C:1]([O:5][C:6]([C@H:7]1[C@H:22]([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([Cl:15])[C:17]=2[F:33])[C@:23]([C:26]2[CH:27]=[CH:28][C:42]([Cl:43])=[CH:30][CH:31]=2)([C:24]#[N:25])[C@H:9]([C:10]([CH3:13])([CH3:12])[CH3:11])[NH:8]1)=[O:14])([CH3:4])([CH3:3])[CH3:2]