Potassium Cyanide → 4-Chloro-2-methylbenzeneacetonitrile
반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Cl)=[C:4]([CH3:10])[CH:3]=1.[C-:11]#[N:12].[K+]>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][C:11]#[N:12])=[C:4]([CH3:10])[CH:3]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
Step B To a solution of 4-chloro-2-methylbenzyl chloride (5.2 g, 30 mmol) in ethanol (40 mL) was added an aqueous solution (30 mL) of KCN (5 g, 77 mmol) at room temperature. The reaction mixture was then heated at 100° C. for 2 h. The mixture was cooled to room temperature and concentrated. The residue was partitioned between ethyl acetate and water. The organic layer was separated, concentrated. The residue was purified by chromatography (EtOAc:hexanes=1:10, then 1:4) to give 4-chloro-2-methylbenzyl cyanide as a yellow oil (3.5 g, 66%).
후처리
- temperatureThe mixture was cooled to room temperature
- concentrationconcentrated
- customThe residue was partitioned between ethyl acetate and water
- customThe organic layer was separated
- concentrationconcentrated
- customThe residue was purified by chromatography (EtOAc
출처 및 근거
- ORD 기록
- ord-af47db2144e14e4083848c84f1b7a058
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08354444B2
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