Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethan-1-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | (4R)-4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane | HCID 11480522 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethan-1-amine | HCID 28293775 | — |
반응 단계
Step A In a manner similar to the method described in Example 3a Step A to C, (4R)-(−)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (Aldrich) (4.91 g, 33.6 mmol) was reacted with methanesulfonyl chloride (3.12 mL, 40.3 mmol) and triethylamine (9.34 mL, 67 mmol) in dichloromethane, then reacted with NaN3 (10.7 g, 0.16 mol) in N,N-dimethylformamide, then treated with PtO2 and H2 (50 psi) in ethyl acetate to give 2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine as a brown oil (4.4 g, 90% for three steps).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08354444B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-0a422cad0a334c4ea1124acbdb87778e |
| 출처 메모 | uspto-grants-2013_01 |