Ethyl 3,3,4-trimethylpentanoate → 3,3,4-Trimethylpentan-1-ol

HRID 1806850노트

반응식

HRID 1806850 반응식
C([O:3][C:4](=O)[CH2:5][C:6]([CH3:11])([CH3:10])[CH:7]([CH3:9])[CH3:8])C.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C(OCC)C>[CH3:10][C:6]([CH3:11])([CH:7]([CH3:9])[CH3:8])[CH2:5][CH2:4][OH:3]

참가 물질

4

반응물 2

HCID 10012374Ethyl 3,3,4-trimethylpentanoateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 124253343,3,4-Trimethylpentan-1-ol수율 101.1%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
0 °C

실험 절차

Step B To a solution of 3,3,4-trimethyl-pentanoic acid ethyl ester (7 g, 41 mmol) in anhydrous ethyl ether (100 mL) at 0° C. was added a ethyl ether solution (1 M) of LiAlH4 (67 mL, 67 mmol) under nitrogen. The reaction mixture was stirred at 0° C. for 1 h, then poured into a ice-water. The mixture was extracted with ethyl acetate. The organic layer were separated, washed with water, aqueous HCl solution, brine, dried over MgSO4, and concentrated to give 3,3,4-trimethyl-pentan-1-ol as a colorless oil (5.4 g, 100%).

후처리

  1. extractionThe mixture was extracted with ethyl acetate
  2. customThe organic layer were separated
  3. washwashed with water, aqueous HCl solution, brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-29866ab419074df19707c4844ffbc446
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354444B2

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