Sodium Sulfite → 3,3,4-Trimethylpentanal

HRID 1806851노트

반응식

HRID 1806851 반응식
[CH3:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[CH2:3][CH2:4][OH:5].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[O-]S([O-])=O.[Na+].[Na+]>ClCCl>[CH3:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[CH2:3][CH:4]=[O:5]

참가 물질

5

반응물 3

HCID 24437Sodium SulfiteHCID 159087TriacetoxyperiodinaneHCID 124253343,3,4-Trimethylpentan-1-ol

생성물 1

HCID 124253353,3,4-Trimethylpentanal수율 21%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Step C To a solution of 3,3,4-trimethyl-pentan-1-ol (5.4 g, 41 mmol) in dichloromethane (100 mL) was added Dess-Martin periodinane (22 g 52 mmol) The reaction mixture was stirred at room temperature for 3 h. Aqueous Na2SO3 solution was added to quench the reaction. The organic layers were separated, washed with saturated NaHCO3, brine, dried over MgSO4, and concentrated. The residue was purified by chromatography (EtOAc:hexanes=1:30) to give 3,3,4-trimethyl-pentanal as a colorless oil (Yield: 1.1 g, 21%).

후처리

  1. customto quench
  2. customthe reaction
  3. customThe organic layers were separated
  4. washwashed with saturated NaHCO3, brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated
  7. customThe residue was purified by chromatography (EtOAc:hexanes=1:30)

출처 및 근거

ORD 기록
ord-04793b282781441ba373943a0ab4286c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354444B2

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