Imidazole → HCID 131730158, 화합물

HRID 1806971노트

반응식

HRID 1806971 반응식
[CH2:1]([C:3](CO)([CH2:7][CH3:8])[CH2:4][C:5]#N)[CH3:2].N1[CH:15]=[CH:14][N:13]=C1.[C:16]([Si:20](C)(C)Cl)([CH3:19])([CH3:18])[CH3:17].[OH2:24].Cl[CH2:26]Cl>>[C:16]([SiH2:20][O:24][C:1]([CH3:2])([CH3:26])[C:3]([CH2:4][CH3:5])([CH2:7][CH3:8])[CH2:15][C:14]#[N:13])([CH3:19])([CH3:18])[CH3:17]

참가 물질

6

반응물 5

HCID 795ImidazoleHCID 962WaterHCID 6344DichloromethaneHCID 28928tert-Butyldimethylsilyl chlorideHCID 866404003-Ethyl-3-(hydroxymethyl)pentanenitrile

생성물 1

HCID 131730158HCID 131730158, 화합물수율 74%

실험 절차

Step C To the solution of 3-ethyl-3-hydroxymethyl-pentanenitrile (1.7 g, 12 mmol) and imidazole (1.2 g, 18 mmol) in dichloromethane (80 mL) was added tert-butyldimethylchlorosilane (2 g, 13 mmol). The reaction mixture was stirred at room temperature for 2 h. Water was added. The organic layer was separated, the aqueous layer was then extracted with dichloromethane. The combined organic layers were washed with brine, dried over MgSO4, concentrated to give 3-(tert-butyl-dimethyl-silanyloxymethyl)-3-ethyl-pentanenitrile as a colorless oil (2.28 g, 74%).

후처리

  1. customThe organic layer was separated
  2. extractionthe aqueous layer was then extracted with dichloromethane
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-687b4f5937e140e285f18dfbeb95fcc9
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354444B2

반응 노트

불러오는 중…