Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Chloropyridine-3-carbaldehyde → 2-(Chloropyrid-5-yl)-(4-chlorophenyl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Chloropyridine-3-carbaldehyde | HCID 2764053 | — |
| 반응물 | 2-(Chloropyrid-5-yl)-(4-chlorophenyl)bromomethane | HCID 22506785 | — |
| 반응물 | HCID 178478191 | HCID 178478191 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(Chloropyrid-5-yl)-(4-chlorophenyl)methanol | HCID 22506792 | — |
반응 단계
2-(Chloropyrid-5-yl)-(4-chlorophenyl)bromo-methane may be prepared by carrying out the procedure in a manner similar to Example 84, starting with 22.5 cm3 of 4-chlorophenylmagnesium bromide (1 M solution in ethyl ether) in 30 cm3 of tetrahydrofuran, under an inert argon atmosphere, and 2.9 g of 2-chloropyridine-5-carboxaldehyde in 30 cm3 of tetrahydrofuran. 3.42 g of 2-(chloropyrid-5-yl)-(4-chlorophenyl)methanol are thus obtained in the form of a pale green powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741316B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-ce483d21a0764f32b303eb4437437310 |
| 출처 메모 | uspto-grants-2010_06 |