Methyl 2-ethoxy-4-nitrobenzoate → Methyl 4-amino-2-ethoxybenzoate

HRID 1807272

반응식

HRID 1807272 반응식
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7])[CH3:2].[H][H]>[Pd].CO>[NH2:14][C:12]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:3][CH2:1][CH3:2])[CH:13]=1

참가 물질

5

반응물 2

HCID 9964566Methyl 2-ethoxy-4-nitrobenzoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 67368855Methyl 4-amino-2-ethoxybenzoate수율 94.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of methyl 2-ethoxy-4-nitrobenzoate (2.038 g, 9.05 mmol) and palladium on carbon (583 mg, 10 wt %, Aldrich) in methanol (62 ml) was reacted with hydrogen at 40 psi for 18 hrs on the PARR shaker. It was filtered through celite and washed with methanol under N2 and the filtrate was concentrated to give methyl 4-amino-2-ethoxybenzoate (1.672 g, 94%) as a light brown solid.

후처리

  1. filtrationIt was filtered through celite
  2. washwashed with methanol under N2
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9acd94964bc04e788752929f301a7dac
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354444B2

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