Triethylamine → 2-(Benzooxazol-2-ylaminomethyl)-piperidine-1-carboxylic acid tert-butyl ester

HRID 18073

반응식

HRID 18073 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[O:18][C:19]2[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=2[N:21]=1.C(N(CC)CC)C>O1CCCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][NH:15][C:17]1[O:18][C:19]2[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=2[N:21]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 119862-ChlorobenzoxazoleHCID 2756482tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate

생성물 1

HCID 665702372-(Benzooxazol-2-ylaminomethyl)-piperidine-1-carboxylic acid tert-butyl ester수율 110.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(RS) 2-Aminomethyl-piperidine-1-carboxylic acid tert butyl ester (0.21 g) and 2-chlorobenzoxazole (0.153 g) and triethylamine (0.1 g) were combined in tetrahydrofuran (10 ml) and stirred at room temperature for 4 hours. The mixture was partitioned between ethyl acetate and water, the organic phase dried and solvent removed at reduced pressure to give the title compound (0.36 g) as an oil that solidified on standing.

후처리

  1. customThe mixture was partitioned between ethyl acetate and water
  2. customthe organic phase dried
  3. customsolvent removed at reduced pressure

출처 및 근거

ORD 기록
ord-97882efc0c7c4fa1915436993b0beb93
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741329B2

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