2-Chloroquinoline → 2-(Quinolin-2-ylaminomethyl)-piperidine-1-carboxylic acid tert butyl ester

반응식

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][NH:15][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 119282-Chloroquinoline

HCID 2756482tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate

생성물 1

HCID 865936682-(Quinolin-2-ylaminomethyl)-piperidine-1-carboxylic acid tert butyl ester

실험 절차

The title compound (0.1 g) was prepared from (RS) 2-aminomethyl-piperidine-1-carboxylic acid tert butyl ester (0.5 ml) and 2-chloroquinoline (0.5 g) according to the procedure of D8.

출처 및 근거

ORD 기록: ord-ed2cdbf0e20d4f43a5d8cec5281f1579
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07741329B2

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