(S)-tert-butyl (4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)(2-(dimethylamino)-2-oxoethyl)carbamate → (S)-2-((4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)amino)-N,N-dimethylacetamide

HRID 1807615

반응식

C1(C2C=C(C3ON=C(C4C=CC=C5C=4CC[C@H]5NCCO)N=3)SC=2C(F)(F)F)C=CC=CC=1.[CH2:34]([O:36][C:37]1[CH:38]=[C:39]([CH:69]=[CH:70][C:71]=1[O:72][CH2:73][CH3:74])[CH2:40][C:41]1[O:45][N:44]=[C:43]([C:46]2[CH:54]=[CH:53][CH:52]=[C:51]3[C:47]=2[CH2:48][CH2:49][C@@H:50]3[N:55]([CH2:63][C:64]([N:66]([CH3:68])[CH3:67])=[O:65])C(=O)OC(C)(C)C)[N:42]=1)[CH3:35]>>[CH2:34]([O:36][C:37]1[CH:38]=[C:39]([CH:69]=[CH:70][C:71]=1[O:72][CH2:73][CH3:74])[CH2:40][C:41]1[O:45][N:44]=[C:43]([C:46]2[CH:54]=[CH:53][CH:52]=[C:51]3[C:47]=2[CH2:48][CH2:49][C@@H:50]3[NH:55][CH2:63][C:64]([N:66]([CH3:67])[CH3:68])=[O:65])[N:42]=1)[CH3:35]

참가 물질

반응물 2

HCID 67197972(S)-tert-butyl (4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)(2-(dimethylamino)-2-oxoethyl)carbamate

HCID 67319515(R)-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino) ethanol

생성물 1

HCID 67198667(S)-2-((4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)amino)-N,N-dimethylacetamide

실험 절차

(S)-2-((4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)amino)-N,N-dimethylacetamide 66 was prepared analogously to compound 67 from (S)-tert-butyl (4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)(2-(dimethylamino)-2-oxoethyl)carbamate INT-64.

출처 및 근거

ORD 기록: ord-49fcdcd2f89f4e159572342f60c8f10b
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08357706B2

연결된 노트

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