Cyclopropanemethanamine → Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

HRID 1807707노트

반응식

HRID 1807707 반응식
[CH:1]1([CH2:4][NH2:5])[CH2:3][CH2:2]1.[N:6]([C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1)=[C:7]=[O:8]>ClCCl>[CH:1]1([CH2:4][NH:5][C:7](=[O:8])[NH:6][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 75646CyclopropanemethanamineHCID 589805Ethyl 4-isocyanatobenzoate

생성물 1

HCID 3830959Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate수율 107.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To cyclopropylmethanamine (57.5 mmol, 4.99 ml, 4.09 g) in dichloromethane (40 mL) was added to ethyl 4-isocyanatobenzoate (52.3 mmol, 10 g) in dichloromethane (45 mL) and the reaction stirred overnight. The reaction was then concentrated under reduced pressure to give the title compound (14.7 g).

후처리

  1. concentrationThe reaction was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-874251e8ba324526a3cbd46f7f0217f8
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08357679B2

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