Trifluoroacetic acid → HCID 86638571, 화합물

HRID 1807781노트

반응식

HRID 1807781 반응식
[F:1][C:2]([F:31])([F:30])[C:3]([C:9]1[CH:29]=[CH:28][C:12]([CH2:13][N:14]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][C:15]2=[O:27])=[CH:11][CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].FC(F)(F)C(O)=O>ClCCl>[F:30][C:2]([F:1])([F:31])[C:3]([C:9]1[CH:10]=[CH:11][C:12]([CH2:13][N:14]2[CH2:19][CH2:18][NH:17][CH2:16][C:15]2=[O:27])=[CH:28][CH:29]=1)([OH:8])[C:4]([F:7])([F:6])[F:5]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86638570tert-Butyl 4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-3-oxopiperazine-1-carboxylate

생성물 1

HCID 86638571HCID 86638571, 화합물수율 85.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirring solution of tert-butyl 4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-3-oxopiperazine-1-carboxylate (3.05 mmol, 1.39 g) in dichloromethane (15 mL) was added trifluoroacetic acid (30.5 mmol, 3.47 g) and the mixture allowed to stir at room temperature for 5 hours. The reaction mixture was concentrated and the resulting residue purified by strong cation exchange column chromatography to afford the title compound (932 mg). MS (ESI) m/z 357.0 [M+H]+

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe resulting residue purified by strong cation exchange column chromatography

출처 및 근거

ORD 기록
ord-299ef11c7202411da43f4a4f853779d9
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08357679B2

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