Cyanogen Bromide → (S)-4-[2-(5-trifluoromethyl-pyridin-2-yloxy)-ethyl]-4,5-dihydro-oxazol-2-ylamine
반응식
[NH2:1][C@@H:2]([CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=1)[CH2:3][OH:4].[N:18]#[C:19]Br>>[F:16][C:14]([F:17])([F:15])[C:11]1[CH:12]=[CH:13][C:8]([O:7][CH2:6][CH2:5][C@H:2]2[CH2:3][O:4][C:19]([NH2:18])=[N:1]2)=[N:9][CH:10]=1참가 물질
3
실험 절차
In analogy to example 1d (S)-2-amino-4-(5-trifluoromethyl-pyridin-2-yloxy)-butan-1-ol was reacted with cyanogen bromide to give (S)-4-[2-(5-trifluoromethyl-pyridin-2-yloxy)-ethyl]-4,5-dihydro-oxazol-2-ylamine. White solid. MS (ISP): 276.2 ([M+H]+).
출처 및 근거
- ORD 기록
- ord-42c5adeead934c0192e340f42aabf280
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08357712B2
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