참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Chloropyrimidine | HCID 74404 | — |
| 반응물 | tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate | HCID 2756482 | — |
| 생성물 | tert-Butyl 2-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate | HCID 71631688 | — |
반응 단계
A mixture of (RS) 2-aminomethyl-piperidine-1-carboxylic acid tert butyl ester (1.28 g) and 2-chloropyrimidine was heated at 100° C. for 48 hours. After cooling to room temperature the mixture was column chromatographed (silica gel, 0-10% (9:1 methanol/ammonia) in dichloromethane eluant) to give the title compound (0.42 g) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07741329B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-11bc6b9d360c42b7badcc2370c78ce4d |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
