Oxalyl chloride → HCID 59752362, 화합물

HRID 1808002노트

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HRID 1808002 반응식
[C:1]([O:4][C@H:5]1[CH2:10][C@H:9]([CH3:11])[CH2:8][CH2:7][C@H:6]1[C:12]([OH:14])=O)(=[O:3])[CH3:2].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[C:1]([O:4][C@H:5]1[CH2:10][C@H:9]([CH3:11])[CH2:8][CH2:7][C@H:6]1[C:12]([Cl:18])=[O:14])(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 57457642(1R,2S,4R)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid

생성물 1

HCID 59752362HCID 59752362, 화합물수율 100.8%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of (1R,2S,4R)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid (109 mg, 0.54 mmol) in dichloromethane (2.7 ml) was added oxalyl chloride (545 ul, 1.09 mmol) followed by 1 drop of dimethylformamide. The reaction mixture was stirred for 4 h at room temperature. The solvents were then removed to obtain 119 mg (99%) of (1R*,2S*,4R*)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid chloride.

후처리

  1. customThe solvents were then removed

출처 및 근거

ORD 기록
ord-64076f522c694225876d013d0659d4bb
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08357718B2

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