2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene → 2-(1-Methyl-2-trimethylsilylethyl)phenylamine

HRID 1808295노트

반응식

HRID 1808295 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[CH:12][Si:13]([CH3:16])([CH3:15])[CH3:14])[CH3:11])([O-])=O.[H][H]>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]([CH2:12][Si:13]([CH3:15])([CH3:14])[CH3:16])[CH3:11]

참가 물질

5

반응물 2

HCID 684549542-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 578833472-(1-Methyl-2-trimethylsilylethyl)phenylamine수율 88%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

후처리

  1. filtrationThe catalyst was filtered off
  2. customafter evaporation of the solvent
  3. customthe product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

출처 및 근거

ORD 기록
ord-d052c0d53109463aa8f7fef434d0f715
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08357816B2

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