Acetic Acid → Methyl 5-formyl-1H-imidazole-4-carboxylate
반응식
C(O)(=O)C.[CH2:5]([O:7][CH:8]([O:18]CC)[C:9]1[N:10]=[CH:11][NH:12][C:13]=1[C:14](OC)=[O:15])C.C1(C)C=CC=CC=1>O>[CH:14]([C:13]1[N:12]=[CH:11][NH:10][C:9]=1[C:8]([O:7][CH3:5])=[O:18])=[O:15]참가 물질
5
반응 조건
- 온도
- 25 °C
실험 절차
Acetic acid (244 mmol, 34.7 equiv.) was added to a solution of methyl 4-(diethoxy-methyl)-1H-imidazole-5-carboxylate (7.04 mmol, 1 equiv.) in water (4.2 ml), and the resulting mixture was stirred for 6 h at 25° C. under nitrogen. Toluene was added to the reaction mixture, and the solvent was removed in vacuo in order thus to yield the desired product in the form of a yellow solid. This was used in the following stage without further purification. Yield: quantitative
후처리
- customthe solvent was removed in vacuo in order thus
출처 및 근거
- ORD 기록
- ord-2f46f2d9a1594ba69776bbf27ddf9117
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08357717B2
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