참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Cumylamine | HCID 68509 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-Methyl-1-phenyl-ethylisocyanate | HCID 2769430 | — |
반응 단계
To a benzene (2 mL) solution of cumylamine (1.80 g, 13.3 mmol) and triethylamine (1.86 mL, 13.3 mmol) was added a 20% toluene solution of phosgene (17.5 mL, 33.3 mmol) dropwise. After completion, the reaction mixture was heated to 60° C. for 2 hours. It was then cooled to room temperature, charged with diethyl ether (20 mL), and filtered. Concentration of the filtrate in vacuo afforded the title compound. This crude product was used in the subsequent step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08361994B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_01 |
|---|
| ORD ID | ord-fe3dccab2b714d998f38ddba15056b2c |
|---|
| 출처 메모 | uspto-grants-2013_01 |
|---|
