2-Chloroquinazoline → (S)-2-(quinazolin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester

HRID 18088

반응식

HRID 18088 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[N:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH:15][C:17]1[N:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 740542-ChloroquinazolineHCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate

생성물 1

HCID 86593672(S)-2-(quinazolin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester수율 55.2%

실험 절차

The title compound (0.6 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (0.68 g) and 2-chloroquinazolin (0.53 g) according to the method of D30.

출처 및 근거

ORD 기록
ord-19677e9145174c38bc11ef68fdf901a1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741329B2

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