HCID 59587921, 화합물 → HCID 44595147, 화합물

HRID 1808909노트

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HRID 1808909 반응식
[N:1]([C@@H:4]1[C@@H:8]([O:9][CH2:10][C:11]#[CH:12])[CH2:7][N:6]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:5]1)=[N+:2]=[N-:3]>C1(C)C=CC=CC=1>[N:2]1[N:1]2[C@H:4]3[CH2:5][N:6]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:7][C@@H:8]3[O:9][CH2:10][C:11]2=[CH:12][N:3]=1

참가 물질

3

반응물 1

HCID 59587921HCID 59587921, 화합물

생성물 1

HCID 44595147HCID 44595147, 화합물수율 96%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of (3S,4S)-tert-butyl 3-azido-4-(prop-2-ynyloxy)pyrrolidine-1-carboxylate (77 mg, 0.29 mmol) in toluene (5 ml) was heated at 120° C. for 16 hours or until TLC analysis shows completed reaction. The solvent was removed under reduced pressure and the residue was purified by flash chromatography, silica gel, gradient hexane:ethyl acetate (3:1) to neat ethyl acetate, to afford the titled compound (74 mg, 96%) as white solid. M.p. 155-157° C.

후처리

  1. customreaction
  2. customThe solvent was removed under reduced pressure
  3. customthe residue was purified by flash chromatography, silica gel, gradient hexane:ethyl acetate (3:1) to neat ethyl acetate

출처 및 근거

ORD 기록
ord-34f109b2fe3542a19384ee287f36ecb0
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362011B2

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