Potassium Carbonate → 2-((2-Methoxyethoxy)methoxy)-3-nitrobenzoic acid methyl ester

HRID 1809130노트

반응식

HRID 1809130 반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[OH:13].C([O-])([O-])=O.[K+].[K+].Cl[CH2:22][O:23][CH2:24][CH2:25][O:26][CH3:27]>CN(C)C=O>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[O:13][CH2:22][O:23][CH2:24][CH2:25][O:26][CH3:27]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 775901-(Chloromethoxy)-2-methoxyethaneHCID 596904Methyl 2-hydroxy-3-nitrobenzoate

생성물 1

HCID 582228052-((2-Methoxyethoxy)methoxy)-3-nitrobenzoic acid methyl ester수율 98.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

9.9 g (50 mmol) of 2-hydroxy-3-nitrobenzoic acid methyl ester was dissolved in 100 mL of dimethylformamide. 7.6 g (55 mmol) of K2CO3 and 6.3 mL (55 mmol) of chloromethoxyethoxymethane were added thereto and stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, followed by dilution with ethyl acetate and washing with distilled water and saturated sodium chloride solution. The resulting residue was dried over magnesium sulfate and concentrated under reduced pressure to obtain the title compound (14.0 g, yield: 98%).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washwashing with distilled water and saturated sodium chloride solution
  3. dry with materialThe resulting residue was dried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d0db3811871d480ba610292ef9464f09
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362012B2

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