Ammonium Hydroxide → 3-Cyanobenzene-1-sulfonamide

HRID 1809201

반응식

HRID 1809201 반응식
[NH4+:1].[OH-].[C:3]([C:5]1[CH:6]=[C:7]([S:11](Cl)(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1)#[N:4]>C(#N)C>[C:3]([C:5]1[CH:6]=[C:7]([S:11]([NH2:1])(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1)#[N:4]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 28013603-Cyanobenzene-1-sulfonyl chloride

생성물 1

HCID 28087183-Cyanobenzene-1-sulfonamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

NH4OH (22 mL, excess) can be added to a solution of 3-cyanobenzene-1-sulfonyl chloride (1.0 g, 4.97 mmol) in acetonitrile (22 mL) and the reaction stirred overnight at r.t. The reaction can be concentrated and the solid obtained washed with water to give 500 mg of product. The water phase can be extracted with AcOEt, dried with MgSO4 anh, filtered and evaporated to give 400 mg of product that can be combined with the solid obtained before (0.90 g, 99%).

후처리

  1. customThe reaction
  2. concentrationcan be concentrated
  3. customthe solid obtained
  4. washwashed with water

출처 및 근거

ORD 기록
ord-677cb9023bfe48a5bb62101c1c42c633
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362018B2

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