Bromine → 1-(1-Acetylpiperidin-4-yl)-2-bromoethan-1-one

HRID 1809551노트

반응식

HRID 1809551 반응식
[N:1]1([C:10](=[O:12])[CH3:11])[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH3:8])[CH2:3][CH2:2]1.[Br:13]Br>CO>[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH2:8][Br:13])[CH2:3][CH2:2]1)(=[O:12])[CH3:11]

참가 물질

4

반응물 2

HCID 24408BromineHCID 27772501,4-Diacetylpiperidine

생성물 1

HCID 772303261-(1-Acetylpiperidin-4-yl)-2-bromoethan-1-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a 1000 mL flask, 1,1′-(piperidine-1,4-diyl)diethanone (38.0 g, 225 mmol) was dissolved in methanol (700 mL) and bromine (12.1 mL, 236 mmol) was added. After agitating for 3 hours the solvent was removed in vacuo. The resulting solid was washed with ethyl acetate, then distributed between ethyl acetate and sodium carbonate. The organic phase was separated, washed with brine, dried and evaporated to give the title compound.

후처리

  1. customwas removed in vacuo
  2. washThe resulting solid was washed with ethyl acetate
  3. customThe organic phase was separated
  4. washwashed with brine
  5. customdried
  6. customevaporated

출처 및 근거

ORD 기록
ord-1b241b13d0d54244b9caf410ba9038c1
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362037B2

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