Potassium Carbonate → 1-(3-Phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea

HRID 1809580노트

반응식

HRID 1809580 반응식
C([NH:9][C:10]([NH:12][C:13]1[C:18]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:17][C:16]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.C([O-])([O-])=O.[K+].[K+]>CCO>[O:19]([C:18]1[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=[C:16]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)[CH:17]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 866410891-Benzoyl-3-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea

생성물 1

HCID 866410901-(3-Phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea수율 29.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-benzoyl-3-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea (2.10 g, 4.58 mmol) and K2CO3 (3.16 g, 22.9 mmol) was refluxed in EtOH (50 mL) for 18 hours. The reaction was cooled to ambient temperature, filtered and concentrated. The residue was purified by silica gel to provide 1-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea (0.484 g, 29.8% yield).

후처리

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customThe residue was purified by silica gel

출처 및 근거

ORD 기록
ord-7350c94515b844f889bd51dcab7af746
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362037B2

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