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Dimethylformamide → 3-Phenoxy-5-(trifluoromethyl)picolinonitrile

HRID 1809597
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HRID 1809597 반응식
Cl[C:2]1[C:3]([C:12]#[N:13])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.O.O.O.[O-:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[Na+].CN(C=O)C>CCOCC>[O:17]([C:2]1[C:3]([C:12]#[N:13])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1
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참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 14733743-Chloro-5-(trifluoromethyl)pyridine-2-carbonitrileHCID 23681143Sodium Phenoxide Trihydrate

생성물 1

HCID 674852863-Phenoxy-5-(trifluoromethyl)picolinonitrile수율 67.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
80 °C

실험 절차

3-Chloro-5-(trifluoromethyl)picolinonitrile (0.220 g, 1.07 mmol) was combined with sodium phenoxide trihydrate (0.272 g, 1.60 mmol) and DMF (5 mL). The resulting mixture was heated to 80° C. and agitated for one hour. The mixture was then cooled, diluted with ether and washed with 1M NaOH, water (3×), brine, dried and evaporated to give crude 3-phenoxy-5-(trifluoromethyl)picolinonitrile (0.190 g, 67.5% yield) as red oil.

후처리

  1. temperatureThe mixture was then cooled
  2. washwashed with 1M NaOH, water (3×), brine
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-cf45a6206dbd441bbbec73d4dd1a5671
출처 데이터셋
uspto-grants-2013_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08362037B2

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