Hydrazine → HCID 178478326, 화합물

HRID 1809661노트

반응식

HRID 1809661 반응식
Br[C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[Br:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH:14]=O.[NH2:19][NH2:20]>>[Br:10][C:11]1[CH:12]=[C:13]([C:14]2[C:2]3[C:3](=[N:4][C:5]([Cl:8])=[N:6][CH:7]=3)[NH:20][N:19]=2)[CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 3

HCID 9321HydrazineHCID 765833-BromobenzaldehydeHCID 2899735-Bromo-2,4-dichloropyrimidine

생성물 1

HCID 178478326HCID 178478326, 화합물

실험 절차

Alternatively, for compounds of formula Ib where X and Y are CH, in accordance to Scheme 3 below, 5-bromo-2,4-dichloro-pyrimidine (1) is reacted with 3-bromo-benzaldehyde (4) by a Grignard reaction and the corresponding coupled alcohol is oxidized to the ketone. The ketone is reacted with hydrazine to give 3-(3-bromo-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine. The remaining chloro group can then be replaced by reacting with the appropriate amine and the bromide can be displacement with the required amine under Buckwald conditions to give compounds Ib of this invention.

출처 및 근거

ORD 기록
ord-aef62ac29587452a9a6b8da7027f7210
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362023B2

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