Hydrazine → HCID 178478327, 화합물
반응식
[Br:1][C:2]1[N:7]=[C:6]([C:8]([C:10]2[C:11](Cl)=[N:12][C:13]([Cl:16])=[N:14][CH:15]=2)=O)[CH:5]=[CH:4][CH:3]=1.[NH2:18][NH2:19]>C1COCC1>[Br:1][C:2]1[N:7]=[C:6]([C:8]2[C:10]3[C:11](=[N:12][C:13]([Cl:16])=[N:14][CH:15]=3)[NH:19][N:18]=2)[CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a stirred solution of (6-bromo-pyridin-2-yl)-(2,4-dichloro-pyrimidin-5-yl)-methanone (from Example 29 supra) (2.42 g, 7.54 mmol) in THF (30 mL) was added hydrazine (454 mg, 9.08 mmol) and the mixture was stirred for 30 minutes at room temperature and then at 50° C. for 1 hour. The solvent was then removed and the solid was washed with water and dried to give crude 3-(6-bromo-pyridin-2-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine as a yellow solid. (Yield 1.7 g, crude).
후처리
- waitat 50° C. for 1 hour
- customThe solvent was then removed
- washthe solid was washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-1e3d297cf3f3499da7665a2bdce51aec
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08362023B2
반응 노트
불러오는 중…