tert-butyl (3S,4S)-3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate → 1-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine

HRID 1809833노트

반응식

HRID 1809833 반응식
C([NH:8][C@@H:9]1[C@@H:13]([OH:14])[CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[NH2:8][C@@H:9]1[C@@H:13]([OH:14])[CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]1

참가 물질

4

반응물 1

HCID 11277777tert-butyl (3S,4S)-3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate

생성물 1

HCID 104654571-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine수율 98.9%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

A solution of the intermediate (5.4 g, 18.5 mmol) of step B, Pd(OH)2/C (0.3 g) in MeOH (200 mL) was stirred under hydrogen at 55 psi overnight. The catalyst was filtered off and the filtrate was concentrated to give 3.7 g of the desired product as a solid. MS calculated (M+H)+203. Found 203.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-dca94266f9df420fb7d523ba09d2d5a5
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362003B2

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