Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N'-Dimethylethylenediamine → ethyl 3-[4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 1-Ethyl-4-ethynylbenzene | HCID 142425 | — |
| 반응물 | Ethyl 3-iodobenzoate | HCID 143542 | — |
| 반응물 | Sodium Ascorbate | HCID 23667548 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | (Methanesulfinyl)methane--water (1/1) | HCID 23503278 | — |
| 생성물 | ethyl 3-[4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl]benzoate | HCID 67030215 | — |
반응 단계
A mixture of ethyl 3-iodobenzoate (4-1) (138 mg, 0.5 mmol), sodium azide (34 mg, 0.52 mmol), 1-ethyl-4-ethynylbenzene (4-2) (65 mg, 0.5 mmol), CuI (10 mg), MeNHCH2CH2NHMe (11 μL), sodium ascorbate (10 mg), DMSO-H2O (v/v 5:1, 1.5 mL) is stirred at room temperature for 2 hours. The reaction mixture is then poured into ethyl acetate (50 mL), washed with water (10 mL) and brine (10 mL), dried over Na2SO4, filtered and evaporated. The residue is purified on silica gel (0-33% ethyl acetate in hexane) to give ethyl 3-[4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl]benzoate as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08362050B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-04d8a6fc35784539b2a7b23ce7e955f3 |
| 출처 메모 | uspto-grants-2013_01 |