2-(Trifluoromethoxy)thiophenol → HCID 178460765, 화합물

HRID 1810025노트

반응식

HRID 1810025 반응식
COC1C=CC=CC=1S[CH2:10][CH2:11][CH2:12][N:13]([C@H:29]1[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]1)[C:14](=[O:28])[NH:15][C:16]1[S:17][C:18]([S:21][C:22]([CH3:27])([CH3:26])[C:23]([OH:25])=[O:24])=[CH:19][N:20]=1.[F:36][C:37]([F:47])([F:46])[O:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[SH:45].C(OC(=O)C(SC1SC(N)=NC=1)(C)C)C>>[CH3:26][C:22]([S:21][C:18]1[S:17][C:16]([NH:15][C:14]([N:13]([C@H:29]2[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]2)[CH2:12][CH2:11][CH2:10][S:45][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=2[O:38][C:37]([F:36])([F:46])[F:47])=[O:28])=[N:20][CH:19]=1)([CH3:27])[C:23]([OH:25])=[O:24]

참가 물질

4

반응물 3

HCID 27607322-(Trifluoromethoxy)thiophenolHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178489631HCID 178489631, 화합물

생성물 1

HCID 178460765HCID 178460765, 화합물

실험 절차

The compound was prepared following an analogous procedure to the one described for the synthesis 2-{2-[3-[3-(2-methoxy-phenylsulfanyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2-methyl-propionic acid using 2-trifluoromethoxy-thiophenol and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

후처리

  1. customThe compound was prepared

출처 및 근거

ORD 기록
ord-93e86e0a15f140a99c2adbd02a4e9676
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362049B2

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