4-Fluorobenzyl carbonochloridate → (2'-{[Ethyl-(4-fluoro-benzyloxycarbonyl)-amino]-methyl}-6,5'-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester

HRID 1810505노트

반응식

HRID 1810505 반응식
[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH2:21][NH:22][CH2:23][CH3:24])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.Cl[C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=1)=[O:28]>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH2:21][N:22]([CH2:23][CH3:24])[C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)=[O:28])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1

참가 물질

3

반응물 2

HCID 132929264-Fluorobenzyl carbonochloridateHCID 58148841(2'-Ethylaminomethyl-6,5'-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester

생성물 1

HCID 58149192(2'-{[Ethyl-(4-fluoro-benzyloxycarbonyl)-amino]-methyl}-6,5'-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester

실험 절차

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6,5′-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester and 4-fluorobenzyl chloroformate.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-5a81cdc502a9489ea2d3a26e783fb358
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362044B2

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