1-(prop-2-yn-1-yl)-1H-pyrazole → methyl (E)-[4-[3-(4-fluorophenyl)-3-[4-[3-(pyrazol-1-yl)propynyl]phenyl]-allyloxy]-2-methylphenoxy]acetate

Methyl (Z)-[4-[3-(4-Fluorophenyl)-3-(4-iodophenyl)allyloxy]-2-methylphenoxy]acetate (400 mg, 0.75 mmol; example 10) was dissolved in a mixture of anhydrous tetrahydrofuran (10 mL) and anhydrous triethylamine (20 mL). The solution was degassed and a solution of 1-propargylpyrazol (160 mg, 1.50 mmol) in anhydrous tetrahydrofuran (2 mL) was added under inert atmosphere. The resulting solution was degassed and copper(I) iodide (23 mg, 0.12 mmol) and tetrakis(triphenylphosphine)palladium (70 mg, 0.06 mmol) were added and the mixture was degassed again. The reaction mixture was stirred at ambient temperature overnight; the resulting suspension was filtered through a paddle of silica gel. Silica gel was thoroughly washed with ethyl acetate; the filtrate was evaporated and the residue was dissolved in dichloromethane (30 mL). The solution was washed with water (2×30 mL) and brine (2×30 mL), dried over anhydrous magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography (silica gel Fluka 60, hexanes/ethyl acetate 80:20) yielding methyl (E)-[4-[3-(4-fluorophenyl)-3-[4-[3-(pyrazol-1-yl)propynyl]phenyl]-allyloxy]-2-methylphenoxy]acetate as orange oil.

1. customThe solution was degassed
2. customThe resulting solution was degassed
3. customthe mixture was degassed again
4. filtrationthe resulting suspension was filtered through a paddle of silica gel
5. washSilica gel was thoroughly washed with ethyl acetate
6. customthe filtrate was evaporated
7. dissolutionthe residue was dissolved in dichloromethane (30 mL)
8. washThe solution was washed with water (2×30 mL) and brine (2×30 mL)
9. dry with materialdried over anhydrous magnesium sulfate
10. customevaporated in vacuo
11. customThe residue was purified by column chromatography (silica gel Fluka 60, hexanes/ethyl acetate 80:20)

ORD 기록

ord-57d3a11cca034430b410d7f5b27f81fb

출처 데이터셋

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08362016B2