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Potassium Carbonate → 2-(3-Fluoro-5-hydroxy-4-methoxy-benzoylamino)-indane-2-carboxylic acid methyl ester

HRID 1810861
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HRID 1810861 반응식
C([O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([F:16])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=O)(=O)C.Cl.[CH3:18][O:19][C:20]([C:22]1([NH2:31])[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23]1)=[O:21].C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:18][O:19][C:20]([C:22]1([NH:31][C:8](=[O:10])[C:7]2[CH:6]=[C:5]([OH:4])[C:13]([O:14][CH3:15])=[C:12]([F:16])[CH:11]=2)[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23]1)=[O:21]
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참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 45074056methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochlorideHCID 670767283-Acetoxy-5-fluoro-4-methoxy-benzoic acid

생성물 1

HCID 670766132-(3-Fluoro-5-hydroxy-4-methoxy-benzoylamino)-indane-2-carboxylic acid methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound of step 3 (120 mg, 0.526 mmol) was reacted with 2-amino-indane-2-carboxylic acid methyl ester hydrochloride in analogy to step 1 of example 15. The obtained product was dissolved in methanol (0.77 ml), potassium carbonate (2 mg) was added, and the mixture was stirred at room temperature for 30 min. The solvent was evaporated, the residue was partitioned between EA and a saturated sodium chloride solution, and the aqueous phase extracted with EA. The combined organic extracts were dried over sodium sulfate, filtered and evaporated to dryness to give 60 mg of the title compound.

후처리

  1. customThe solvent was evaporated
  2. customthe residue was partitioned between EA
  3. extractiona saturated sodium chloride solution, and the aqueous phase extracted with EA
  4. dry with materialThe combined organic extracts were dried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-af7a28fd13b746acb9264dc840979944
출처 데이터셋
uspto-grants-2013_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08362073B2

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