Formamidine acetate → HCID 178487763, 화합물
반응식
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(O)(=O)C.[CH:17](N)=[NH:18]>COCCO>[CH3:12][O:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4]([OH:5])=[N:18][CH:17]=[N:1]2)=[CH:7][CH:8]=1참가 물질
4
반응 조건
- 온도
- 130 °C
실험 절차
Step 1 A mixture of 2-amino-4-methoxybenzoic acid (0.5 g, 2.99 mmol) and formamidine acetate (0.623 g, 5.98 mmol) in 2-methoxyethanol (4 mL) was heated at 130° C. After 15.25 h, the mixture was cooled to rt. The resulting precipitate was collected by filtration, washed with methanol and dried to provide 7-methoxyquinazolin-4-ol as a tan solid (473 mg, 90%). 1H NMR (400 MHz, DMSO-d6) δ 12.08 (1 H, br. s.), 8.06 (1 H, s), 8.03 (1 H, d, J=9.5 Hz), 7.03-7.14 (2 H, m), 3.90 (3 H, s).
후처리
- temperaturethe mixture was cooled to rt
- filtrationThe resulting precipitate was collected by filtration
- washwashed with methanol
- customdried
출처 및 근거
- ORD 기록
- ord-dbb7e3abeda4448e845102690cab76c6
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08362065B2
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