Dimethylformamide → 6-Chloro-2-fluoro-3-methylbenzamide

HRID 1811533노트

반응식

HRID 1811533 반응식
[Cl:1][C:2]1[C:7]([C:8](O)=[O:9])=[C:6]([F:11])[C:5]([CH3:12])=[CH:4][CH:3]=1.C(Cl)Cl.C(Cl)(=O)C(Cl)=O.C[N:23](C=O)C>>[Cl:1][C:2]1[C:7]([C:8]([NH2:23])=[O:9])=[C:6]([F:11])[C:5]([CH3:12])=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 27736696-Chloro-2-fluoro-3-methylbenzoic acid

생성물 1

HCID 27736646-Chloro-2-fluoro-3-methylbenzamide

실험 절차

To 6-chloro-2-fluoro-3-methylbenzoic acid (10 g, 53 mmol) is added CH2Cl2 (60 mL), DMF (0.5 mL) and oxalyl chloride (9.25 mL, 106 mmol). The reaction mixture is allowed to stir until it reaches homogeneity and is then concentrated in vacuo. The residue is poured onto a 50:50 mixture of ice and 36% ammonium hydroxide to yield 6-chloro-2-fluoro-3-methylbenzamide.

후처리

  1. concentrationis then concentrated in vacuo
  2. additionThe residue is poured onto a 50:50 mixture of ice and 36% ammonium hydroxide

출처 및 근거

ORD 기록
ord-fe9138bc2818476d8569eb362bb0ab3b
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362294B2

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