Dimethylformamide → Ammonium Hydroxide

HRID 1811534노트

반응식

[Cl:1][C:2]1[C:7](C(O)=[O:9])=[C:6]([F:11])[C:5]([CH3:12])=[CH:4][CH:3]=1.C(Cl)Cl.C(Cl)(=O)C(Cl)=O.C[N:23]([CH:25]=[O:26])C>>[OH-:9].[NH4+:23].[Cl:1][C:2]1[C:7]([C:25]([NH2:23])=[O:26])=[C:6]([F:11])[C:5]([CH3:12])=[CH:4][CH:3]=1

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 6344Dichloromethane

HCID 65578Oxalyl chloride

HCID 27736696-Chloro-2-fluoro-3-methylbenzoic acid

생성물 2

HCID 14923Ammonium Hydroxide수율 36%

HCID 27736646-Chloro-2-fluoro-3-methylbenzamide

실험 절차

To 6-chloro-2-fluoro-3-methylbenzoic acid (10 g, 53 mmol) is added CH2Cl2 (60 mL), DMF (0.5 mL) and oxalyl chloride (9.25 mL, 106 mmol). The reaction mixture is allowed to stir until it reaches homogeneity and is then concentrated in vacuo. The residue is poured onto a 50:50 mixture of ice: 36% ammonium hydroxide to yield 6-chloro-2-fluoro-3-methylbenzamide.

후처리

concentrationis then concentrated in vacuo
additionThe residue is poured onto a 50:50 mixture of ice

출처 및 근거

ORD 기록: ord-36a79107114642328e54f2ecccfbd40d
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08362294B2

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