Bromine → 6-Bromo-2,4-dimethylpyridin-3-amine

To a solution of 2,4-dimethylpyridin-3-amine (2.0 g, 16 mmol) in CH2Cl2 (20 mL), was added a solution of bromine (3.16 g; 20 mmol) in CH2Cl2 (5 mL) at 0° C. for 5 min. The reaction was concentrated under vacuum. The reaction was poured into H2O (50 mL), extracted with CH2Cl2, washed with Na2SO3 solution, and dried over MgSO4. The CH2Cl2 was concentrated under vacuum to afford the crude compound. The crude was purified over SiO2 to afford to give 6-bromo-2,4-dimethylpyridin-3-amine. 1HNMR (CDCl3, 400 MHz) δ 2.10 (s, 3H), 2.31 (s, 3H), 4.85-5.10 (b, 2H), 7.05 (s, 1H). Exact mass calculated for C7H9BrN2 201.06. found 202.3 (MH+).

1. concentrationThe reaction was concentrated under vacuum
2. additionThe reaction was poured into H2O (50 mL)
3. extractionextracted with CH2Cl2
4. washwashed with Na2SO3 solution
5. dry with materialdried over MgSO4
6. concentrationThe CH2Cl2 was concentrated under vacuum
7. customto afford the crude compound
8. customThe crude was purified over SiO2
9. customto afford

ORD 기록

ord-2c4a5becfc7546ecb8a27cf100868a25

출처 데이터셋

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08362248B2