참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | Oxindole | HCID 321710 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 5-Nitro-2-oxindole | HCID 230366 | 98% |
반응 단계
To a solution of oxindole (26 g) in 100 mL of concentrated sulfuric acid at −15° C. was added fuming nitric acid (8.4 mL) dropwise. Careful attention was paid to maintain the reaction temperature at −15° C. After the addition was complete, the reaction was stirred for 30 minutes and then poured into ice water. A yellow precipitate was formed which was isolated by filtration to provide 34 grams (98%) of 5-nitro oxindole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07741336B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-07318aef6f47429ab5e8b23b180b76d0 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
